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The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out. There are some associations with chronic eosinophilic leukemia as it shows similar characteristics and genetic defects.〔 Last updated: Updated: Oct 4, 2009 by Venkata Samavedi and Emmanuel C Besa〕 If left untreated, HES is progressively fatal. It is treated with glucocorticoids such as prednisone.〔 The addition of the monoclonal antibody mepolizumab may reduce the dose of glucocorticoids. ==Classification== In the heart, there are two forms of the hypereosinophilic syndrome, endomyocardial fibrosis and Loeffler's endocarditis. * Endomyocardial fibrosis (also known as Davies disease) is seen in tropical areas. * Loeffler's endocarditis does not have any geographic predisposition. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「hypereosinophilic syndrome」の詳細全文を読む スポンサード リンク
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